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KMID : 0377519900150030287
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Chung-Ang Journal of Medicine
1990 Volume.15 No. 3 p.287 ~ p.296
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Studies on Oxygen Radicals, Antioxidants Activities and Pathologic Changes in the Lungs of Paraquat Treated Rats
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Abstract
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In the present study, the changes in the production of the superoxide radicals, hydrogen peroxes and the activities of superoxide dismutase and catalase and pathologic findings in the rats´ lungs at were treated with paraquat, 37mg/kg body weight were observed.
The results were summarized as follows:
At 24hr after the administration of paraquat, the homogenates of rats´ lung showed -a considerably higher activity of Mn-SOD than those of the control rats (p<0.01).
At 48hr, Mn´-SOD were significantly lower than those of the control rats (p<0.01), but activity of Mn-SOD become higher than those in the control guoup at 72hr and 168hr (p<0.05, p<0.01). In the lungs´ of rats treated with paraquat, the production of superoxide radicals appeared to be high in comparison with those in the control group at 48hr and 168hr (p<0.01).
Activity of catalase in the lungs of rats treated with paraquat were higher than those in the control group from 24hr to 168hr (p<0.01).
The production of hydrogen peroxide were higher than those in the control group at 48hr and Ll : 72hr (p<0.01).
48hr after paraquat administration, histologic evidence of injury was significantly demonstrated {rl by increased cellular debris in the alveolar spaces, focal arears of hemorrhagic pneumonitis and
progressive infiltration of the lung parenchyma and alveolar spaces with PMN leuckocytes. F" From the above results, the rats treated with high dose paraquat showed severe ARDS like acute lung injury by oxidant-antioxidant imbalance. If increasing antioxidant activity at early 48hr or preventing from secondary oxygen radical releasing by reducing neutrophil alveolitis were done, acute lung injury by paraquat could be reduced_
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